Suggested by elb on #guix.
* doc/guix.texi (Binary Installation): Add note explaining the
implications of disabling substitutes.
~root/.config/guix/current/share/guix/@value{SUBSTITUTE-SERVER}.pub
@end example
+@quotation Note
+If you do not enable substitutes, Guix will end up building
+@emph{everything} from source on your machine, making each installation
+and upgrade very expensive. @xref{On Trusting Binaries}, for a
+discussion of reasons why one might want do disable substitutes.
+@end quotation
+
@item
Each user may need to perform a few additional steps to make their Guix
environment ready for use, @pxref{Application Setup}.